sandimmune neoral, a microemulsion-based cya soft capsule (25 mg)  (Novartis)

Journal: Current Clinical Pharmacology

Article Title: Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers

doi: 10.2174/1574884715666200110153125

Figure Lengend Snippet: Pharmacokinetics of cyclosporine administered with water or pomegranate juice in 13 healthy Thai volunteers.

Article Snippet: After an 8-hour overnight fast, subjects received 200 mg of microemulsion cyclosporine (Sandimmune soft gelatin capsules, Sandoz Pharmaceuticals Corp., Hanover, N.J.) with either 500 ml of pomegranate juice (test) or 500 ml of water (control).

Techniques: Drug discovery

Journal: Current Clinical Pharmacology

Article Title: Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers

doi: 10.2174/1574884715666200110153125

Figure Lengend Snippet: Adverse events during clinical study after patients taking cyclosporine with pomegranate juice and the drug with water (sample size =13).

Article Snippet: After an 8-hour overnight fast, subjects received 200 mg of microemulsion cyclosporine (Sandimmune soft gelatin capsules, Sandoz Pharmaceuticals Corp., Hanover, N.J.) with either 500 ml of pomegranate juice (test) or 500 ml of water (control).

Techniques:

Journal: Current Clinical Pharmacology

Article Title: Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers

doi: 10.2174/1574884715666200110153125

Figure Lengend Snippet: Statistical comparison of selected pharmacokinetic parameters of cyclosporine between pomegranate juice (test) versus water (control).

Article Snippet: After an 8-hour overnight fast, subjects received 200 mg of microemulsion cyclosporine (Sandimmune soft gelatin capsules, Sandoz Pharmaceuticals Corp., Hanover, N.J.) with either 500 ml of pomegranate juice (test) or 500 ml of water (control).

Techniques: Comparison, Control

Journal: Current Clinical Pharmacology

Article Title: Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers

doi: 10.2174/1574884715666200110153125

Figure Lengend Snippet: Statistical comparison of t max of cyclosporine between pomegranate juice versus water by wilcoxon signed rank test.

Article Snippet: After an 8-hour overnight fast, subjects received 200 mg of microemulsion cyclosporine (Sandimmune soft gelatin capsules, Sandoz Pharmaceuticals Corp., Hanover, N.J.) with either 500 ml of pomegranate juice (test) or 500 ml of water (control).

Techniques: Comparison

Journal: International Journal of Nanomedicine

Article Title: Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine

doi: 10.2147/IJN.S82558

Figure Lengend Snippet: Schematic representation of the absorption and digestion mechanisms of fats and fatty carrier (SEDDS) in the GIT. Notes: ( A ) Drug diffusion from intact carrier; ( B ) nanoemulsion forms endogenous mixed micelle; ( C ) absorption of intact drug; loaded nanocarrier. Abbreviations: TG, triglycerides; MG, monoglycerides; ME, microemulsion; FFA, free fatty acid; SEDDS, self-emulsifying drug delivery system; GIT, gastrointestinal tract; D, drug.

Article Snippet: The authors loaded another lipophilic API (Cyclosporine) in bilosomes in comparison with conventional liposomes and marketed a microemulsion product (Sandimmune ® and Neoral ® [Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA]).

Techniques: Diffusion-based Assay